One runner undertaking the challenge will be Bedwas resident Laura Lees.
Laura, 33, who works for charity Deafblind Cymru, will be taking part in the event wearing glasses that replicate an eye condition called Retinitis Pigmentosa and ear defenders to replicate being hard of hearing.
She said: “I work with people with combined sight and hearing loss on a daily basis. I can see the challenges they face throughout their everyday lives and how just trying to do the simplest of tasks can be a struggle. I decided to run with ear defenders and simulation specs, to represent combined sight and hearing loss.”